منابع مشابه
p73 in colorectal cancer
Colorectal cancer (CRC) is the third most common cancer in the world, with about 5000 new cases in Sweden every year. CRC is caused by mutation (inherited or acquired) in genes, by gene variants and changed expression of proteins. The primary way to achieve a curative result for CRC is to remove the tumor by surgery. To reduce risk of recurrence chemoor radiotherapy are given as a complement to...
متن کاملDecreased expression of p73 in colorectal cancer.
INTRODUCTION The colorectal cancer (CRC) is one of the most frequent cancer in Poland and worldwide. This disease is characterized by distinct genetic alterations. p73 belongs to the p53 gene family; however, its role in the pathogenesis of CRC has not been completely understood. p73 gene encodes several mRNA variants and protein isoforms with its longest and fully functional p73a (mRNA) and TA...
متن کاملRole of p73 Dinucleotide Polymorphism in Prostate Cancer and p73 Protein Isoform Balance
Background. Molecular markers for prostate cancer (PCa) risks are currently lacking. Here we address the potential association of a dinucleotide polymorphism (DNP) in exon 2 of the p73 gene with PCa risk/progression and discern any disruption of p73 protein isoforms levels in cells harboring a p73 DNP allele. Methods. We investigated the association between p73 DNP genotype and PCa risk/aggress...
متن کاملCell density-dependent regulation of p73 in breast cancer cells.
Molecular regulation of p73, a p53 family member, remains unclear. Here we report that p73 expression is significantly regulated by cell densities. In particular, we found that p73alpha and p73beta are differentially regulated. While p73beta protein levels were inversely correlated with cell densities, p73alpha protein levels behaved oppositely. We further showed that density-dependent changes ...
متن کاملp73 Expression in Human Normal and Tumor Tissues: Loss of p73 Expression Is Associated with Tumor Progression in Bladder Cancer
Purpose: To characterize the expression profile of p73 in human normal tissues by immunohistochemistry (IHC) and to analyze the correlation between p73 expression and bladder cancer progression. Experimental Design: CJDp73 was characterized for p73 detection in Western blot and IHC through its application to isoform-transfected 293 cells. Normal tissues were analyzed by IHC with the CJDp73 anti...
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ژورنال
عنوان ژورنال: Genes & Cancer
سال: 2011
ISSN: 1947-6019,1947-6027
DOI: 10.1177/1947601911408890